GCSE Combined Science revision · Biology: cells, organisation and disease

Digestion, the heart and blood

The idea

Enzymes are biological catalysts with an active site that fits one substrate (lock and key). Amylase breaks starch into sugars, proteases break proteins into amino acids, and lipases break lipids into fatty acids and glycerol. Bile, made in the liver, neutralises stomach acid and emulsifies fats. The heart's right side pumps blood to the lungs; the left side pumps it to the body. Blood is plasma carrying red cells, white cells and platelets.

  1. Match each enzyme to its substrate and products.
  2. Trace blood through the heart.
  3. Link each blood vessel or blood part to its function.

Watch out Bile is not an enzyme: it emulsifies fats, increasing their surface area for lipase.

See it worked

Worked example

Explain why an enzyme stops working at a high temperature.

  1. The high temperature changes the shape of the active site.
  2. The substrate no longer fits, so the enzyme is denatured.

Answer The active site changes shape, so the substrate no longer fits (denatured)

Your turn

Question 1Calculator allowed1 mark

Which enzyme breaks lipids into fatty acids and glycerol?

Choose one
Question 2Calculator allowed1 mark

Which blood vessel carries blood from the heart to the lungs?

Choose one
Question 3Calculator allowed1 mark

What is the function of platelets?

Choose one

In past papers

127 official questions in 65 papers since 2018. The latest:

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Independent practice for AQA GCSE Combined Science: Trilogy (8464), not endorsed by AQA.

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